Patton Oswalt slays an audience (including myself you can hear me howling loudly at the 1:05 mark) while opening for Yo La Tengo at Maxwell's in Hoboken, NJ on December 9, 2004. This was an amazing evening all around, with this bit being just one of many highlights. I'm glad some kind soul posted this so I could share the comedic bounty.
Language is NSFW, so wear headphones, kids!
I should mention that tomorrow (January 27) is Patton's 41st birthday. Hippy barthday, funny person!